منابع مشابه
Osteoporosis pathophysiology: the updated mechanism
Backgrounds underlying the age-related bone loss can be classified into two categories: systemic abnormality and osteoblast dysfunction. The former includes insufficiency of vitamin D or estrogen, causing a negative balance of calcium metabolism. We propose the contribution of an ageing-suppressing gene, klotho, as a novel systemic factor, since the mouse deficient in the klotho gene exhibits m...
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Osteoporosis is an important age-related disease constituting a major health problem in most developed societies especially among postmenopausal women who are expected to live well into the 80s. An estimated total of about 75 million people in the USA, Europe and Japan are afflicted by the disease. It is often the underlying cause of spine, wrist and hip fractures. Spinal fracture leads to pain...
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Aging is associated with significant bone loss in women and in men [1]. Fig. 1, which draws on numerous cross-sectional and longitudinal studies using areal bone mineral density (aBMD) by dual energy x-ray absorptiometry (DXA), depicts the overall pattern of bone loss in both sexes. The menopause in women is associated with a rapid loss of trabecular bone, as is present in the vertebrae, pelvis...
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Osteoporosis is a skeletal disorder characterized by decreased mass and compromised bone strength predisposing to an increased risk of fractures. Although idiopathic osteoporosis is the most common form of osteoporosis, secondary factors may contribute to the bone loss and increased fracture risk in patients presenting with fragility fractures or osteoporosis. Several medical conditions and med...
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Osteoporosis remains underrecognized and undertreated but more so in men, adding considerably to fracture burden and costs. Fracture-related morbidity and mortality is higher in men, partly due to greater frailty. Improved peak bone mass, geometry and turn-over contribute to lower fracture incidence in men. Bioavailable androgens and oestrogens regulate these aspects of musculoskeletal sexual d...
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ژورنال
عنوان ژورنال: Osteoporosis and Sarcopenia
سال: 2018
ISSN: 2405-5255
DOI: 10.1016/j.afos.2018.11.007